The latest generation of rheumatoid arthritis medications

The latest generation of drugs, developed using modern pharmaceutical technologies, alleviate human suffering, reduce the risk of further complications. What is rheumatoid arthritis, what are the causes, symptoms, what treatment methods are possible?

What is a disease?

This is a systemic neurological pathology associated with inflammation of the cartilage in the articular joint. The causal relationships of the clinical condition are different. However, all of them are caused by problems in the work of the protective immune organization of a person. The most likely provoking factor is an infectious lesion.

The reaction to the inflammatory process of infection is a slow destruction of connective tissues associated with their degenerative-dystrophic reorganization.

If adequate treatment is not done on time, then the next stage of degeneration will be deformation of the articular surface. This entails a significant limitation of the mobility of the osteoarticular segments of the lower limb ODA.

Possible causes of neurological pathology:

  • genetic dependence;
  • the impact of chronic diseases on the articular segments;
  • action of triggering factors: hypothermia, intoxication, reaction of the osteoarticular system to mutagenic drugs.

With rheumatoid arthritis, the symptoms of the disease without drug therapy can persist for a long time and are expressed in the following manifestations:

  • joint pain of varying degrees of intensity, even with minor loads;
  • the presence of swelling, redness at the site of the lesion;
  • violation of the temperature regime as a result of an inflammatory reaction in the connective tissue.

Such symptomatic signs are possible with any inflammatory reactions. Therefore, before treating rheumatoid arthritis, it is necessary to identify the diagnostic signs of the disease.

A person needs to see a doctor who, on the basis of the collected medical history, diagnostic laboratory tests (ultrasound, X-ray, MRI, CT), other specifying diagnostic procedures, will determine the severity of the neurological pathology. He will establish a causal relationship of the inflammatory reaction, prescribe medication.

During treatment, motor activity of the articular segments is required. To this end, the consulting specialist prescribes physiotherapeutic procedures, therapeutic massage, gymnastic exercises, manual methods of influencing articular pathology.

Detailed video about the nature of the disease:

Systemic drug therapy

A therapeutic therapeutic reaction involves the use of five groups of pharmacological drugs.

№ p / pPharmacological combinationsPrescription of medicines
1Nonsteroidal anti-inflammatory (NSAIDs)Symptom management
2Basic anti-rheumatic groupsDecrease in inflammatory activity, mitigation of osteoarticular destruction
3GlucocorticosteroidsNormalization of metabolic functions, restoration of active blood circulation
4Biological treatmentsElimination of enzymatic destruction of nearby tissue joints of the articular surface
5Muscle relaxantsTo relax skeletal muscles with a significant decrease in motor activity

Nonsteroidal anti-inflammatory

When anesthetizing and eliminating the inflammatory reaction, doctors prescribe the most famous drugs of non-steroidal anti-inflammatory activity – Diclofenac®, Ibuprofen® or Paracetamol®.

However, there are more effective treatments from a non-steroidal anti-inflammatory group with the least side effect associated with the organs of the genitourinary and gastrointestinal systems.

Among the non-steroidal anti-inflammatory combinations stands out Dexalgin® 25 of the German manufacturer – the company BERLIN-CHEMIE / MENARINI PHARMA GmbH. It is available in the form of tablets with the active ingredient dexketoprofen, dispensed in the pharmacy network only as prescribed by the doctor. Due to the active component and auxiliary substances (corn starch, microcrystalline cellulose, etc.), the non-steroidal dosage form has an analgesic, anti-inflammatory and antipyretic effect.

After taking the pharmaceutical, the main symptoms of rheumatoid arthritis – pain, swelling, redness – disappear after 30-40 minutes. However, the duration of anesthesia is 4-5 hours – and there comes a new round of pain attacks. The dosage and course of treatment is determined by the attending specialist taking into account the age, gender, individual characteristics of the patient.

The drug is not prescribed for pregnant women, children under 12 years old, sick people with chronic respiratory pathologies, renal and liver failure. The medicine is not intended for prolonged use. The course of treatment should not exceed 5-7 days.

Even “neglected” joint problems can be cured at home! Just remember to smear it once a day.

The next non-steroidal anti-inflammatory drug of the new (last) generation is Voltaren® Acti of the Russian manufacturer GlaxoSmithKlein Helsker JSC. The medicine is available in the form of white tablets. The main active ingredient is diclofenac sodium.

Voltaren® Acti has all the properties of pharmacological agents of non-steroidal anti-inflammatory activity – antipyretic, analgesic. The therapeutic effect occurs after 15-20 minutes, which makes the use of the drug effective for the quickest relief of a pain attack and regulation of the temperature regime. The course of treatment with the drug should not exceed 5 days. Contraindications: gastric ulcer, children under 14 years of age, renal, liver or heart failure. Take it is not recommended for people with chronic respiratory diseases.

Among the novelties of the pharmaceutical industry for external use is the anti-inflammatory analgesic cream Aertal® of the Spanish company ALMIRALL SA.

Thanks to the active substance – aceclofenac – the use of the dosage form is advisable for inflammation in the joint, other musculoskeletal, articular segments of the musculoskeletal system.

Exceptions are diseases of the skin at the site of the intended therapeutic action, individual intolerance to the pharmacological product.

Basic anti-rheumatic drugs

Among the interesting modifying antirheumatic products of the pharmaceutical market:

  • Azathioprine® is a prescription drug of the Russian manufacturer OJSC “MOSHIMFARMPREPARATY im. N.A. Semashko ”, produced in tablet form. The immunosuppressant blocks cell division, proliferation (proliferation) of damaged tissues in the joint cavity. The dosage form has virtually no s />

How and how to treat the disease, the attending physician decides. This group of drugs has a very slow therapeutic effect. It is recommended to use the basic treatment together with other pharmacological groups – non-steroidal anti-inflammatory drugs, glucocorticosteroids.

Glucocorticosteroids

This type of pharmacological preparation is a steroid hormone synthesized by the adrenal cortex, which has a versatile physiological effect:

  • anti-inflammatory;
  • anti-allergic;
  • immunoregulatory;
  • anti-shock;
  • anti-stress.

Among the prescribed pharmacological agents of the latest generation, the most effective are:

  • Prednisolone® bufus is a dosage form of the Russian manufacturer ZAO UPDATE PFK, solution for injection of intramuscular and intravenous administration. A pharmacological drug has a pronounced effect on the metabolism of fats, proteins and carbohydrates. Prednisolone® buffus has an effect on the connective tissue of musculoskeletal structures, promotes water-electrolyte metabolism and blood circulation. The dosage regimen is determined by the attending physician, since the dosage form has many s />

Being the most powerful contra-hormonal hormone, glucocorticosteroids are practically not prescribed for patients with diabetes mellitus.

Biological treatments

With rheumatoid arthritis, the synovial membrane is fermented in the articular cavity, which leads to the destruction of disulfide ligaments in nearby bone-articular tissues and cartilage. This entails a cascade reaction, exacerbates the clinical symptoms of a neurological disease. The body responds with an inflammatory reaction, accompanied by the production of cytokines, the most dangerous TNF – tumor necrosis factor. This condition can provide the patient with a significant reduction in the mobility of the joints and physical disability.

Therefore, special blockers (TNF inhibitors) or anticytonic drugs are introduced into complex treatment:

  • Remicade® of the Russian manufacturer MSD PHARMACYUTICALS LLC is an anti-tumor TNF inhibitor that prov />

Muscle relaxants

The medical term comes from the Latin myorelaxantia, where myo is muscle, relaxantis is relaxing. The purpose of their appointment is to reduce muscle tone in the area of ​​neurological damage. The dosage form is classified as follows (see table).

Depolarizing muscle relaxantsNon-depolarizing muscle relaxants
Ultra short actionShort actionMedium actionLong acting
Dithilin® – short-acting depolarizing muscle relaxantMivacron® – for short-term inhibition of neuromuscular transmissionTrakrium® is a competitive dosage form of peripheral action. The main component – atricuria besylate reduces the sensitivity of cholinergic receptors, ensuring the impossibility of excitation and contraction of muscle fiberPavulon® – non-depolarizing muscle relaxant of prolonged activity, providing relaxation of skeletal muscles

Report on the topic of drug treatment:

Forecast

A prerequisite for a speedy recovery is not only the use of drug pharmaceutical combinations. In complex therapy, it is necessary to include physiotherapeutic procedures, special exercises, therapeutic massage, spa treatment.

In case of the ineffectiveness of the listed methods of therapy or with the progression of pain symptoms in the osteoarticular segment, surgical intervention is provided:

Medical experts note that the life expectancy of patients with rheumatoid pathology reduces human life by an average of 5-10 years.

According to laboratory studies of the American Mayo Clinic (USA, Minnesota), conducted in 2005, the risk of cardiovascular pathologies is 2 times higher in patients suffering from rheumatic and arthrological diseases. These disappointing statistics are largely explained by the chronic stage of rheumatoid arthritis of the musculoskeletal system.

The use of biopharmaceutical treatments will help reduce the risk of chronic pathologies and increase life expectancy. They actively affect vital biological objects – blood, cell structure and connective tissue.

Shishkevich Vladimir, orthopedic and traumatologistShishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews.

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Shishkevich Vladimir

Shishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews. It specializes in the treatment of diseases in orthopedic, traumatological, vertebrological profiles

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