Nonsteroidal drug for injections Diklonat P

The drug has different dosage forms.

Shishkevich Vladimir, orthopedic and traumatologistShishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews.

I have been treating joints for many years. I can say with confidence that the joints are always treatable, even in the very ripe old age.

Hondrostrong is an innovative drug that is created to combat joint diseases. It helps with arthritis, arthrosis and other diseases. Thanks to the use of cream, joint mobility quickly returns. Damaged cartilage tissue is regenerated, which prevents the further development of the problem.

Hondrostrong gel for joints

Our medical center was the first to receive certified access to the latest drug for osteochondrosis and joint pain - Hondrostrong. I confess to you when I heard about it for the first time, I just laughed, because I did not believe in its high efficiency.

But I was amazed when we completed testing: 4567 people were completely cured of diseases of the organs of the musculoskeletal system, and this is more than 94% of all subjects. 5.6% felt significant improvement, and only 0.4% did not notice any improvement.

Hondrostrong cream allows you to forget about back and joint pain in the shortest possible time, literally from 4 days, and even very difficult cases can be cured within a couple of months. In addition, the manufacturer of this product is now offering a 50% discount of the full cost of Hondrostrong cream.

Injection Solution

The product has a high degree of transparency, has no color, or it is light yellow. The aroma of benzyl alcohol is light, unobtrusive. The medication is available in ampoules, in a volume of 3 ml. Ampoules are located in pallets of 5 pcs. The packaging is made of cardboard. Each contains one pallet and one instruction for using the product.

Muscle solution

The drug has a high degree of transparency, does not have color, or it is light yellow. The product is available in 2 ml ampoules. Ampoules are located in pallets of 1, 3 or 5 pcs. The packaging is made of cardboard. Each contains one or two pallets and one instruction for using the product.

Pills

They are a means of delayed effect. The tablets inside are white, but covered with a pink shade. The shape is round, the surface is smooth. The product is placed in a blister, which contains 10 tablets. The packaging is made of cardboard. Each contains 2 blisters and one instruction for the use of tablets.

Candles (suppositories)

The product has a bullet-like shape, mild aroma of fat and a light yellow tint. Consistency – gel-like, homogeneous. At the bottom of the candle is a funnel-shaped recess. The product is available in strips. There are 5 candles in one strip. The packaging is made of cardboard. Each contains 2 strips and one instruction for using candles.

The drug is intended for external use. The consistency is creamy. The product has an average degree of transparency (translucent) and white shades. It has a mild aroma of isopropyl alcohol and lavender flowers. The tool is available in aluminum tubes. Volume – 60 ml. Packaging – cardboard. Each contains 1 tube and one instruction for use.

Composition

The main functioning substance is diclofenac sodium. It determines the properties of the drug. Auxiliary elements increase the effectiveness of the drug: benzyl alcohol, sodium hydroxide, propylene glycol, mannitol, water for injection, sodium metabisulfite. This composition is relevant for solutions for injections of Diclonate P.

Means for use by introducing into the muscle are supplemented with substances: sodium hydroxide, propylene glycol, N-acetylcysteine, edetate disodium, water for injection, macrogol-400.

To enhance the effectiveness of the tablets, the elements are added to the composition: magnesium stearate, sucrose, polyvidone, cetyl alcohol, colloidal silicon dioxide. The shell of the preparation contains red iron oxide, hydroxypropyl methylcellulose, titanium dioxide, sucrose, polysorbate, talc, polyethylene glycol.

Besides diclofenac sodium, the gel also contains propylene glycol, isopropyl alcohol, lavender flower flavor, caromber 934, ammonium solution, cetomacrogol, cetiol, purified water, and liquid paraffin.

Pharmacological properties

Pharmacodynamics

Diclofenac is a form of phenylacetic acid. The drug reduces body temperature, stops inflammation and relieves pain. Diclonate P exerts such an action by inhibiting the action of the enzymes COX-1 and COX-2, which interfere with the production of arachidonic acid and the release of inflammatory mediators. Due to this, pain disappears, body temperature normalizes and inflammation decreases.

Another property of the product – prevents the formation of blood clots.

Pharmacokinetics

The tool is fully absorbed in a short time. The product partially leaves the body a couple of hours after application. Completely excreted within a few hours after use.

Candles begin to actively act 30 minutes after administration. Injections act faster – 20 minutes after application. This applies to intramuscular injections. Tablets have a maximum effect 5 hours after administration.

Compliance with the rules of admission and the recommended dosage ensures the absence of accumulation of biologically active substances. Due to this, intoxication of the body and overdose do not occur.

The drug is metabolized in the liver. Most of the remedy leaves the body through the kidneys. Residues are excreted in the bile. In case of impaired renal function, most of Diclonate P leaves the body with bile.

Indications for use

Diclonate P injections and tablets are indicated in the following cases:

  • Pathologies of the muscles and musculoskeletal system, the appearance of which is provoked by inflammation (these include arthritis and osteochondrosis of any nature);
  • Fever;
  • Inflammation in the pelvic organs
  • Pain arising for various reasons;
  • Colic that occurs in the gallbladder or liver;
  • The period after surgery with the appearance of severe pain;
  • Gynecological pathologies for relieving pain;
  • Primary Algodismenorea;
  • Proctitis;
  • Inflammation and pain after an injury;
  • Pathologies of ENT organs, accompanied by severe pain.

Diklonat P gel is used for external use in the following cases:

  1. Pathology of the musculoskeletal system;
  2. Muscle pain syndrome;
  3. Injury to tendons, ligaments and joints.

Contraindications

There are absolute and relative contraindications.

Absolute

  • Hemorrhages of a different nature, including in the gastrointestinal tract;
  • Gastrointestinal pathologies, which are in the acute stage;
  • Diseases in which bleeding periodically occurs, even if they are not in the acute stage;
  • Problems with maintaining blood in a liquid state;
  • Children up to 15 years old Относительные

К относительным противоindicationsм относится:

  1. Пожилой возраст;
  2. Наличие вредных зависимостей;
  3. Период после проведения операции;
  4. Сердечная, почечная и печеночная недостаточность;
  5. Бронхиальная астма;
  6. Малокровие;
  7. Наличие отеков мягких тканей;
  8. Печеночная порфирия в острой форме;
  9. Сахарный диабет в любой форме;
  10. Дивертикулит кишечника;
  11. Патологии ЖКТ.

Instructions for use

Diclonate P solution is used for injection by injecting the drug into the muscle using a syringe. Also used by drip into a vein.

Instructions for the use of injections of Diclonat P: for acute pain – 1 ampoule per day, if pain appears, you can make a second injection. The treatment period is no more than two days.

Intravenous administration of the drug is prescribed by the dropper internal clock. If the pain does not fade, the procedure is repeated in the evening. This method of therapy is carried out in a clinic. Do not use at home. The treatment period should not exceed two days, otherwise an overdose will occur, which will adversely affect the state of the body.

Suppositories of Diclonate P are administered rectally in 1 suppository twice a day. In acute pain, it is recommended to use 2 suppositories once a day.

Gel Diklonat P is applied externally. The product is applied over the problem area and rubbed in with massaging movements. The number of procedures is 2-3 times a day.

S >

Digestive system side effects:

  • Belching and nausea, which often ends with vomiting;
  • Discomfort and pain in the abdomen;
  • Bursting in the stomach;
  • Heartburn;
  • Bloody stains in feces:
  • Plaque and rashes on the tongue;
  • Pain in the mouth;
  • Increased gas formation;
  • Dry mouth, which provokes the appearance of thirst;
  • Problems with stool;
  • GI hemorrhage;
  • The occurrence of erosion and ulcers on the walls of the intestine;
  • Decreased appetite, often leading to anorexia;
  • Cramping and colitis.

Cramps and colitis

Side effects on the nervous system:

  1. Pain in the head;
  2. Dizziness;
  3. Problems with going to sleep, short or poor sleep or constant drowsiness even after a long rest;
  4. The emergence of phobias;
  5. Unstable emotional background;
  6. Depressed state;
  7. Cramps;
  8. Memory problems;
  9. The occurrence of aseptic meningitis.

Side effects on the cardiovascular system:

  • Chest pain;
  • Increased blood pressure;
  • Deterioration in the pathology of the cardiovascular system.

Side effects on the genitourinary system:

  1. The occurrence of pathologies of the urinary and genital organs;
  2. Problems with urination;
  3. Renal impairment.
  4. Side effects on the senses:
  5. Noise in ears;
  6. Violation of smell;
  7. Hearing and sight impairment.

The circulatory system also suffers from the action of Diclonate P. Blood pathologies occur, coagulation worsens. Problems appear in the work of the endocrine system, due to which there is rapid weight loss without changing the lifestyle.

Overdose

Non-compliance recommended Dosages of Diclonate P for internal use, disorders of the gastrointestinal and nervous systems are observed. There are problems with stools, cramps, sleep disturbances or drowsiness, even after prolonged rest. If you do not refuse to take the drug and do not consult a doctor, then an overdose can provoke the development of coma.

The use of Diklonat P in the form of a gel rarely causes an overdose, but it is not recommended to exceed the frequency of use. If the drug accidentally enters the oral cavity, gastric lavage is performed. The lack of timely manipulation leads to side effects and complications.

special instructions

During the use of Diclonate P, it is recommended to monitor the work of internal organs and overall well-being.

The drug should be used with caution by people who have been driving a car for a long time. The tool causes dizziness and worsens the concentration of attention, which can trigger the occurrence of a traffic accident.

It can not be used in conjunction with the use of alcoholic beverages, since alcohol enhances the effects of side effects.

Application during gestation and lactation

The use of the drug is also prohibited at the last stage of gestation of the baby and during lactation, as it can provoke the occurrence of pathologies in the baby and slow down mental and physical development.

Use in childhood and adolescence

Using the drug inside until the child reaches the age of fifteen leads to the appearance of various pathologies of the internal organs, growth retardation or mental development. The product for external use can be used starting from six years.

Use in old age

Old age is not among the absolute contraindications. The use of the drug in this period has only relative contraindications. This means that in some cases, the use of Diclonate P is acceptable. Only a doctor can decide whether to use the drug in old age or not, based on the individual characteristics of the patient and the nature of the pathology. Do not use the product for therapy on your own. This can lead to side effects and complications, which is especially undesirable at this age.

Application for violations of the k >Any problems in the functioning of the kidneys and liver are an occasion for careful use of the drug. If the doctor prescribes Diklonat P therapy in such situations, then he should give special instructions to the patient what to do when their health worsens, and also advise the patient to listen to the sensations of the body.

If you feel worse, you must immediately stop taking the drug and consult a specialist.

Interaction with other drugs

Diclonate P is not used with diuretics, sedatives and hypnotics, since the drug reduces their effectiveness.

Diclonate P when used with other non-steroidal agents provokes the appearance of hemorrhages in the gastrointestinal tract.

Digoxin, lithium and diphenin increase their plasma levels when used together with Diclonate P.

You can not simultaneously carry out therapy with diclofenac sodium and antidepressants of the third generation. This combination leads to hemorrhage in the gastrointestinal tract. A combination of the drug with antiplatelet and glucocorticosteroid medications gives the same result.

You can not use Diklonat P in conjunction with methotrexate, since the content of the latter in the blood increases, which leads to intoxication of the body.

The combination of the product with antidiabetic agents leads to an increase or decrease in blood glucose.

Diclonate P in combination with antibacterial drugs often causes seizures.

Means, the main active components of which are probenecid or sulfinpyrazone, together with Diclonate P slows down the excretion of diclofenac from the body. In such a situation, repeated administration of the product can provoke an overdose with all the corresponding consequences.

Analogues

Diclofenac and Voltaren are the main analogues of Diclonate P. Means also have all the same forms of release and similar properties.

How to store correctly?

Tablets and solutions may stored for 5 years. Candles have a lower shelf life. He is 3 years old. The shelf life of the gel is only 24 months.

Storage temperature – from +15 to + 250С. Keep the product in places where there is no access to children and sunlight.

The cost of the drug depends on the form of release, manufacturer and pricing of the pharmacy that sells the drug. The average price of Diclonate P tablets is 200 rubles, a solution is 100 rubles, candles and gel are 170 rubles.

Shishkevich Vladimir

Shishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews. It specializes in the treatment of diseases in orthopedic, traumatological, vertebrological profiles

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