Instructions for use of the drug Colchicine in the treatment of gout

In the treatment of gout, the drug “Colchicine” has shown its effectiveness. Colchicine tablets help reduce uric acid levels, as well as relieve pain and inflammation in the joints. Features and regimen of taking “Colchicine” for gout are discussed in our article.

Composition of the medicinal product

The active substance of the drug is colchicine. One tablet contains 1 mg of colchicine. The composition also includes auxiliary ingredients: lactose, corn starch, sodium starch (type A), methyl parahydroxybenzoate (E 218), povidone (K-30), propyl parahydroxybenzoate (E 216), colloidal silicon dioxide, hydrogenated castor oil.

Pharmacological properties

Colchicine is able to reduce the movement of leukocytes to the localization of the inflammatory process. Inhibition of the ability of phagocytes to absorb particles of uric acid occurs.

With regular use of the drug, the process of cell division stops, which prevents the development of myosis, and the rate of formation of fibrils of the amyloid structure decreases. The drug showed a good effect for the prevention and mitigation of acute attacks of gout. A positive effect is noticeable already in the first day of use, notes up to 75% of patients.

Drug release form

The drug is made in tablets of 1 mg of active ingredient. The package contains 20 tablets. It is dispensed with a prescription, so a medical consultation is required before use.

Indications for use

The use of “Colchicine” allows you to regulate the metabolism of uric acid in the body, so the drug belongs to the group of antigout drugs.

The main indications of admission:

  • With the prevention and treatment of gout;
  • With gouty arthritis, chondrocalcinosis, scleroderma;
  • For the relief of acute attacks of the disease;
  • In the treatment of family-type Mediterranean fever disease;
  • With amyloidosis (impaired protein metabolism);
  • Some varieties of phlebitis.

The medicine “Colchicine” is also used in some inflammatory processes in dentistry and otolaryngology. Before use, the possible risk and benefit for the patient, as well as the possibility of using similar drugs, are evaluated.

Possible contraindications

Tablets from gout “Colchicine” should not be used for possible contraindications. That is why the reception must be agreed with the attending physician in order to exclude the presence in the anamnesis of the listed diseases and pathologies.

In what cases is the intake contraindicated:

  1. With hepatic or renal failure;
  2. In chronic alcoholism (the drug “Colchicine” is incompatible with alcohol);
  3. Violations and chronic diseases of the digestive tract;
  4. CNS diseases, impaired brain functioning;
  5. With purulent infectious processes;
  6. Indiv >

In the treatment of gout, a simple scheme is used (if the attending physician has not prescribed a different dosage of the drug). On the first day, take one tablet three times a day. On the second and third day of treatment, the dosage is reduced to two tablets per day. In the future, only one tablet is taken per day until the end of the course prescribed by the doctor.

Drug Interactions

“Colchicine” with gout can not be combined with certain groups of drugs. In addition, complete incompatibility with alcohol should be taken into account, therefore, alcohol is prohibited during the treatment period.

With other medicines, the drug may have the following effects:

  • When combined with cyclosporine, the risk of developing myopathy increases;
  • When taking cytostatics, the effectiveness of the drug decreases;
  • The absorption of cyanocobalamin is impaired;
  • The effect of sympathomimetic and depriminating agents is enhanced.

Side effects

“Colchicine” may have side effects. The intensity and frequency of manifestations is very difficult to track, because some conditions can be triggered by the underlying disease, and not by taking the drug.

Side effects mainly include local reactions, digestive upsets, and skin rashes, but in some cases, the remedy can lead to other pathologies.

Side effects of the drug include:

  • Malabsorption syndrome (malabsorption of nutrients in the digestive tract);
  • Neuropathy (degenerative-dystrophic changes in the peripheral nerves);
  • Peripheral neuritis (inflammatory process in the peripheral nerves);
  • Azoospermia (lack of viable sperm in the ejaculate);
  • Myelosuppression (a decrease in blood cells in the bone marrow);
  • Leukopenia (a decrease in the number of white blood cells in the blood);
  • Thrombocytopenia (decreased platelet count in the blood);
  • Anorexia (decreased appetite, poor absorption of nutrients);
  • Myopathy (progressive neuromuscular disease);
  • Neutropenia (a decrease in the level of neutrophilic white blood cells in the blood);
  • Violations in the functioning of the liver and kidneys;
  • Temporary alopecia;
  • Depressive states;
  • Pain in the epigastric region.

A common reaction to taking the drug is the appearance of a rash, resembling a rash with measles. In addition, mood changes, attention disorders, and atypical reactions are often observed. In case of an overdose, the symptoms are pronounced, the use of absorbent drugs is required, in severe cases, gastric lavage under stationary conditions.

Analogs “Colchicine”

The tool is often used in the treatment and prevention of gout, but if reception for some reason is not possible, you should pay attention to suitable analogues. They do not always contain the original active substance (colchicine), but they have a similar effect, reducing the level of uric acid in the body, therefore they are often used in the complex treatment of gout.

It should be borne in mind that taking “Colchicine” and its substitutes can change the biochemical parameters of blood. In addition, acquiring the original drug is quite problematic, and analogues do not always give the desired effect.

Application Reviews

The effectiveness of the drug has been proven not only by scientific research, but also by many positive reviews of patients. Despite the rather expensive cost, the remedy well eliminates pain and the negative manifestations of gout in an acute attack. In addition, in long-term therapy, the stabilizing effect of uric acid in the blood is noted.

In general, despite the risk of adverse reactions when taking, treatment with such a drug is justified and effective.

“Colchicine”, the instructions for use of which are discussed in our article, is a highly effective anti-gum remedy. The drug has a convenient dosage and original composition, which allows you to use it in long-term therapy.

Before use, it is absolutely necessary to exclude possible contraindications and assess the risks of side effects and negative reactions. Possible drug interactions and the regimen for the treatment of gout are given in our article.

Shishkevich Vladimir, orthopedic and traumatologistShishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews.

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Shishkevich Vladimir

Shishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews. It specializes in the treatment of diseases in orthopedic, traumatological, vertebrological profiles