The main active ingredient of the Fastum Gel preparation is ketoprofen, which is part of the group of non-steroidal anti-inflammatory drugs. This NSAID has the most pronounced analgesic effect. An external agent quickly stops inflammation in the joints and muscle tissues, and exhibits analgesic activity. Deep penetration of ketoprofen occurs due to the properties of its molecules, which are characterized by a small size and polarization. Maximum penetration is also provided by a special gel base. Therefore, Fastum gel differs from other external drugs from the NSAID group by the most powerful anti-inflammatory and analgesic properties.
Composition and forms of release
Fastum ointment is a transparent jelly-like substance with a pleasant smell, which is given to it by the essential oils of lavender and neroli. Organic compounds perform the function of flavorings and have a therapeutic effect. Essential oils contain biologically active substances (volatile, bioflavonoids) that improve microcirculation in tissues damaged by inflammation, and replenish molecular oxygen deficiency. The composition of Fastum gel includes the following auxiliary components:
- thickener carbomer 940;
- ethyl alcohol 96%;
- distilled water;
- neutralizing agent trolamine.
The active ingredient ketoprofen is in a pharmacological preparation at a concentration of 2,5%. Auxiliary ingredients contribute to the rapid accumulation of the active substance in inflammatory foci and its uniform distribution. The external agent is well absorbed, does not leave greasy marks on clothes and bedding. Manufacturer – Italian company A.MENARINI INDUSTRIE FARMACEUTICHE RIUNITE – produces Fastum gel in aluminum tubes in a package of 30 g, 50 g, 100 g.
For the long-term treatment of chronic articular pathologies, it is advisable to purchase the largest package of anti-inflammatory drugs. Its cost is approximately equal to the price of two small boxes of Fastum gel.
The secondary packaging of the drug is a cardboard pack with attached instructions for use. The drug must be stored at room temperature, in a place protected from direct sunlight. After opening the tube, the shelf life of the gel is significantly reduced.
Fastum gel is characterized by analgesic, antiexudative and anti-inflammatory activity, which is used for the symptomatic treatment of diseases of the joints, ligaments and muscles. Clinically proven the effectiveness of the drug in the relief of pathologies affecting the ligaments, lymph nodes, tendons, muscles, blood vessels and skin. The use of an anti-inflammatory agent to reduce the severity of articular syndrome leads to the weakening of pain at rest and during movement, to reduce swelling and stiffness after waking up. The use of Fastum gel for bruises promotes the rapid restoration of injured capillaries and veins, normalizes the blood supply to damaged tissues with nutrients and biological substances.
When conducting a randomized double-blind study, it was found that the use of Fastum gel for a week in therapeutic doses showed significantly better results in the treatment of sprain compared to placebo.
The evidence base of the analgesic and anti-inflammatory effects of ketoprofen has been accumulated after clinical trials in animals and volunteers. The active ingredient of Fastum gel, after penetrating the bloodstream and absorbing into the tissue, begins to inhibit the synthesis of prostaglandins – the main mediators of swelling and inflammation. Platelet cyclooxygenase ceases to be produced, thromboxane 2 production decreases.
The research results revealed a feature of the anti-inflammatory activity of ketoprofen. A non-steroidal agent significantly inhibits the synthesis of prostaglandins than other representatives of the NSAID group: Naproxen, Indomethacin, acetylsalicylic acid, Ibuprofen.
Since ketoprofen is a derivative of propionic acid in its chemical structure, it is characterized by the ability to accumulate in inflammatory foci in a higher concentration than in neighboring tissues that have not been damaged. In the medical literature, there is other evidence of the expressed analgesic activity of Fastum gel, based on the pharmacokinetic actions of the main ingredient:
- bradykinin inhibition;
- restoration of cell lysosome membranes.
Bradykinins are the most powerful endogenous substances that contribute to the occurrence of intense pain. One of the auxiliary components of the drug is highly concentrated ethanol. It not only forms and stabilizes the gel base of the ointment, but provides maximum absorption of the active ingredient in the deepest tissues. Due to the complex effect of other auxiliary components, the main substance is absorbed by the dermis in the highest possible concentration. Triethanolamine creates a pH of a jelly-like mass corresponding to the acidity index of human skin – 5,9.
Researchers are particularly interested in the systemic effect of non-steroidal anti-inflammatory drugs for external use. Firstly, the use of this dosage form helps to significantly reduce the dose of NSAIDs for oral administration. Secondly, even when large amounts (150 mg) of ketoprofen are applied to the affected tissues, a maximum concentration of 0,08-0,15 mg / l is detected after several hours in the systemic circulation. We can conclude that Fastum gel retains therapeutic effectiveness for a long time without manifesting pronounced side effects.
In the medical literature, cases of the negative effects of ketoprofen on nephrons or hepatocytes have not been described. Isolated cases of the development of dyspeptic disorders were noted: nausea, epigastric pain, diarrhea.
After using Fastum Gel and accumulating the active ingredient in the inflammatory focus, its absorption into the systemic circulation begins. A non-steroidal agent is characterized by extremely low bioavailability – about 5%. Ketoprofen is not able to accumulate in tissues in concentrations that are hazardous to health. After binding to simple blood proteins with albumin (90%), the active substance of the drug is metabolized in the liver cells. Ketoprofen is utilized by hepatocytes during the chemical glucuronidation reaction. Metabolites are excreted mainly by the kidneys, and only an insignificant part of biologically inactive compounds leaves the body with feces in the composition of bile acids.
Transdermal absorption of the active ingredient and auxiliary components of Fastum Gel is rather slow. However, this is not a disadvantage of a non-steroidal anti-inflammatory drug. The gradual absorption of ketoprofen ensures a long therapeutic maximum concentration in damaged tissues.
Fastum gel is not prescribed for osteochondrosis or sprain of ligaments to pregnant and lactating women because of the ability of its active ingredient to easily pass through all histohematological barriers and be distributed not only in tissues damaged by inflammation, but also in internal organs. Constant blood control during treatment with patients with chronic renal failure is necessary, since when the filtration and urine concentration are disturbed, the rate of elimination of ketoprofen decreases.
Indications for use
Even “neglected” joint problems can be cured at home! Just remember to smear it once a day.
The widest range of applications of Fastum Gel is the treatment of diseases of the musculoskeletal system. The greatest effectiveness of the drug is noted in the treatment of pathologies with acute or chronic processes that adversely affect the patient’s motor activity. A non-steroidal anti-inflammatory drug is used to reduce the severity of symptoms – pain and swelling. But it is also included in etiotropic treatment regimens because of the ability to prevent the spread of inflammation to neighboring healthy tissue sites. What helps Fastum gel:
A non-steroidal anti-inflammatory drug is used in traumatology to reduce the intensity of the pain syndrome and relieve the inflammatory process with sprains, damage to muscles and tendons. The drug is well established in the treatment of thrombophlebitis of superficial veins. After applying the ointment, blood circulation improves, which eliminates the visible signs of venous insufficiency. Dermatologists include an external agent in the therapeutic regimens of patients who have been diagnosed with inflammatory skin pathologies to reduce the intensity of pain. Indications for the use of Fastum gel are diseases of the peripheral nervous system. The drug is recommended for intervertebral hernias, neuralgia, pinching of the nerve roots.
Fastum gel is prescribed by surgeons, neuropathologists and rheumatologists to accelerate recovery after surgery. During the rehabilitation period, daily application of the product helps to quickly repair damaged ligaments, tendons and soft tissues.
Instructions for use
To reduce the intensity of pain, a column of external agent 3-4 cm long should be squeezed out of the tube. The amount of the drug may slightly depend on the area of the affected articular, cartilage or soft tissues. With dermatitis, a higher dose may be required, but only after consulting with your doctor about the advisability and safety of such NSAIDs. The ointment is applied directly over the inflammatory focus and rubbed lightly. The drug is gradually absorbed by the epidermis itself and penetrates the damaged areas of the cartilage or joints.
The instructions for use of Fastum Gel stipulate that you can not apply the drug more than 2 times a day due to the high probability of excessive accumulation of ketoprofen in the tissues. The duration of the course depends on the intensity of pain at a certain stage in the course of pathologies, the general health of the patient and the presence of acute or chronic diseases of the liver and urinary organs. If within 2 weeks of applying the gel the treatment result was not achieved, then it is replaced with an analog or other methods of conservative therapy are used:
- physiotherapeutic procedures;
- oral administration of non-steroidal anti-inflammatory drugs.
With prolonged use of Fastum Gel, an increase in the sensitivity of the skin is possible. Dermatologists recommend that you refrain from visiting the solarium and reduce the length of stay in the open sun during treatment to prevent photosensitivity.
The drug is prescribed to patients for medical manipulations of iontophoresis and phonophoresis. The goal of these procedures is to ensure the complete delivery of ketoprofen to tissues affected by inflammation. Since ointment is characterized by low absorption into the systemic circulation, cases of overdose have not yet been described in the medical literature.
After rubbing a non-steroidal anti-inflammatory drug into the skin, wash your hands with any hygiene product. The essential oils of neroli and lavender, highly concentrated ethyl alcohol, which are part of the gel, can provoke pain and a burning sensation when hit on the mucous membranes of the human body.
In dermatology, Fastum gel is not used in the treatment of pathologies if there are even slight open wound surfaces on the skin. Such diseases include eczema and weeping dermatitis. The use of NSAIDs is contraindicated in the presence of bacterial or fungal infectious agents in inflammatory foci. In these cases, an external agent is prescribed to patients only after a course of antibacterial therapy. The following conditions are absolute contraindications for Fastum gel:
- individual sensitivity to the active ingredient or auxiliary components, the development of a systemic or local sensitization reaction – bronchospasm, contact dermatitis, urticaria, allergic rhinitis;
- intolerance to acetylsalicylic acid;
- hematopoiesis disorders – leukopenia, thrombocytopenia;
- low blood coagulability.
With caution, you can use Fastum Gel during pregnancy only in the first two trimesters. In the later stages, a non-steroidal anti-inflammatory drug is not used, as is the case with breastfeeding. Age up to 12 years is an absolute contraindication of an external drug. Thick ointment is used under medical supervision if the patient has a history of digestive tract pathologies, which are characterized by difficult healing ulcerations of the mucous membranes. In the period of relapse of erosive gastritis, gastric and duodenal ulcers, ointment with ketoprofen is not prescribed.
If Fastum gel is used to treat patients with diseases of the liver and kidneys in the middle or severe stages of the course, then constant laboratory monitoring of blood and urine is performed to identify possible negative changes in blood formation.
A non-steroidal anti-inflammatory drug creates a maximum therapeutic concentration in the bloodstream. This determines the presence of a small amount of side effects of the drug. An allergic reaction like hives usually occurs when medical recommendations are not followed: exceeding single and daily dosages, the duration of the therapeutic course.
Before local application of Fastum gel, a small amount of an external agent is rubbed into the bend of the elbow or wrist on the site of inflammation. If after 30-40 minutes rashes and redness do not form on the skin, then the drug will not cause a sensitization reaction.
Comparative characteristics of analogues
Structural analogues of Fastum gel are not indicated in the instructions, but are easily determined by the active ingredient – ketoprofen. This non-steroidal anti-inflammatory drug is the active substance of the following drugs:
The non-steroidal anti-inflammatory drugs for topical administration include Fastum gel analogues for the provided therapeutic actions: Indomethacin ointment, Diclofenac gel, Piroxicam cream, Ibuprofen ointment, Meloxicam gel. The advantage of Fastum Gel is a higher concentration of the active ingredient. In the pharmacy assortment there is only one drug with a high content of active substance – 5% Diclofenac gel. This concentration is also characterized by a significant number of side effects after the penetration of NSAIDs into the systemic circulation.
Ketoprofen was first synthesized in 1967, and at the same time comparative studies of a non-steroidal anti-inflammatory drug were carried out with drugs that were often prescribed at that time for the treatment of pathologies of the musculoskeletal system: Indomethacin, Ibuprofen and Phenylbutazone (not produced now). In the process of monitoring patients, the great therapeutic efficacy of ketoprofen was proved.
Fastum ointment gel is not considered cheap, but a high concentration of the active ingredient allows it to be used less often and in smaller quantities than other anti-inflammatory non-steroid drugs. Here is the comparative cost of drugs from the NSAID group:
Shishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews.
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