Description of the action of the drug Metindol Retard and reviews on its effectiveness

The drug relieves inflammation, lowers temperature and has an analgesic effect. The principle of action of methindole retard is determined by a decrease in the activity of cyclooxygenase and prostanoid compounds, which cause the onset of pain symptoms, an increase in temperature and vascular permeability in the area of ​​inflammation.

With oral use, the drug is absorbed rapidly. Bioavailability when taking tablets occurs within 12 hours, while about 90% of the dose is adsorbed. The maximum accumulation of the active substance occurs within 2 hours. It is distributed throughout all tissues and organs. It has the ability to penetrate the placental barrier, as well as into the synovial fluid. Through oxidation, it is metabolized in the liver. About 60% is excreted by the kidneys, about 20% – unchanged, the rest – with feces and bile. It has the ability to penetrate into breast milk.


Metindol retard is taken in the symptomatic treatment of a large number of diseases, the course of which is complicated by pain. These are degenerative-dystrophic pathologies of the musculoskeletal system:

  • Ankylosing spondylarthrosis, which is accompanied by the destruction of cartilage;
  • Pain in diseases of the spine .;
  • Rheumatism;
  • Synovitis;
  • Rheumato >

It can be used for primary dysmenorrhea, toothache, myalgia, neuralgia, for the treatment of pericarditis, as well as for adnexitis and other diseases and inflammatory phenomena in the pelvic organs.

It can be prescribed during childbirth as a tocolytic and analgesic, with liver metastases.

It is also used for otitis media, tonsillitis and other ENT diseases in which there is pain.

Instructions for use

The exact dose and duration of admission is determined by the attending specialist taking into account the age of the patient, the course of the disease, and concomitant pathologies.

But in any case, therapy is carried out in the shortest possible time and with the smallest, but effective dosage, to reduce the likelihood of undesirable consequences.

For adults, the Metindol Retard instruction recommends taking 1 tablet once a day. The maximum dosage per day should not be more than 150 mg, given that one tablet contains 75 mg of indomethacin. If the reception is supposed to be long, then no more than 75 mg per day. With dysmenorrhea, the same treatment regimen.

If at the scheduled time you missed the drug, you can take the pill only within two hours after the pass, otherwise you can skip this dose completely, but in no case double the medication.

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  • Intolerance to the components of the drug;
  • If there have been attacks of asthma, urticaria and acute rhinitis after taking other non-stero >


  • The adoption of more than one agent from the non-stero >In case of an overdose (nausea, vomiting, headache, impaired coordination of movements, drowsiness), it is necessary to rinse the stomach and prescribe absorbents, as well as drink plenty of water. When seizures occur, Diazepam is found.

Feature of application

To reduce the likelihood of complications and side effects, you need to take a minimal but effective dosage for a short time.

To reduce dyspeptic disorders, you can drink antacids at the same time.

During therapy, it is imperative to monitor blood counts and the condition of the kidneys and liver.

During treatment with Metindol, it is necessary to exclude work with complex technical devices and driving.

I take the drug with caution in patients who underwent surgery, since there is a risk of bleeding.

Metindol is not taken if the doctor suspects a surgical pathology.

With a rather prolonged use, it can cause the development of thrombosis, so people with a predisposition to this disease should be observed by a specialist who is required to regularly prescribe a blood test.

Shishkevich Vladimir, orthopedic and traumatologistShishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews.

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Shishkevich Vladimir

Shishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews. It specializes in the treatment of diseases in orthopedic, traumatological, vertebrological profiles