Chondroitin-Akos capsules and ointment for the treatment of articular pathologies

Chondroitin-Akos capsules and ointment are used in the treatment of pathologies of the musculoskeletal system. The use of drugs helps to restore damaged tissues of the joints and spine, to prevent their further destruction. Chondroitin-Akos has an anti-inflammatory, analgesic, decongestant effect. Under the influence of its active ingredient chondroitin, blood circulation is normalized, and regeneration processes are accelerated. Capsules and ointments have a wide range of applications, a small number of contraindications for use.

Clinico-pharmacological group

Capsules and ointment are part of the group of pharmacological drugs that regulate the processes of metabolism in the joint structures. Chondroitin-Akos also refers to medicines to reduce the severity of pain in joint diseases, pathologies of the spinal column, ligament-tendon apparatus.

Composition and form of release

Chondroitin-Akos is produced at the Russian pharmaceutical factory Synthesis. The primary packaging is metallized foil blisters with 10 capsules in their cells. The ointment is packaged in 30,0 g in aluminum tubes with a screw cap. The secondary packaging of both dosage forms is a cardboard box with inside instructions for use.

The extracellular matrix of bone, cartilage, ligaments and tendons consists of chondroitin sulfate (Chondroitini sulfate). By its chemical structure, it is a sulfated glucose aminoglycan. The molecular weight of chondroitin sulfate is 14000.

Shishkevich Vladimir, orthopedic and traumatologistShishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews.

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Capsules

Chondroitin-Akos capsules (320 rubles) are issued No. 20, No. 50 and No. 60. They have a hard gelatin shell of blue and blue. Inside there is a yellowish homogeneous powder without a specific odor. Their composition is represented by such ingredients:

  • calcium stearate;
  • milk sugar;
  • chondroitin sulfate.

The hard shell is formed from gelatin, propyl paraben, methyl paraben, titanium dioxide, dyes. Excipients contribute to the rapid absorption of chondroitin sulfate into the systemic circulation, and then into the synovial fluid. Capsules should be stored in a dark place at room temperature not higher than 20 ° C. Shelf life is 36 months. Must be kept out of the reach of children.

The gelatin shell provides a prolonged action of Chondroitin-Akos due to the gradual release of the main component. It also protects it from the aggressive effects of hydrochloric acid in the gastrointestinal tract.

Chondroitin-Akos ointment (115 rubles) is a thick, homogeneous substance with a yellowish tint with a specific smell of dimexide. It contains the following components:

  • chondroitin sulfate;
  • anhydrous lanolin;
  • distilled water;
  • petrolatum;
  • dimethyl sulfoxide.

Auxiliary chemical compounds enhance and prolong the action of the active ingredient. They also contribute to its rapid penetration through all layers of the epidermis into the joint cavity. Some of the components have therapeutic activity. For example, lanolin obtained from sheep’s wool exhibits pronounced antiseptic activity and inhibits the growth of pathogenic bacteria and pathogenic fungi. And dimethyl sulfoxide has an anti-inflammatory effect.

Chondroitin-Akos ointment should be stored at a temperature of 2 ° C to 20 ° C in places protected from direct sunlight. Shelf life of the drug is 36 months. After opening the aluminum tube, it is limited to 4 weeks.

pharmachologic effect

Chondroitin-Akos ointment and capsules are part of the group of chondroprotectors that stimulate the restoration of damaged hyaline cartilage. High molecular weight polysaccharide accelerates metabolic processes in articular structures. It takes part in the production of glucosaminoglycans, stimulation of the production of chondrocytes. Drugs are prescribed to patients in the diagnosis of pathologies provoked by synovial fluid deficiency. Chondroitin sulfate inhibits enzymes that damage the hyaline cartilage, restores the integrity of the joint capsule, smoothes its surface. The course application of Chondroitin-Akos has a multifaceted therapeutic effect:

  • accelerates the healing of tissues undergoing destructive-degenerative changes;
  • stops inflammatory processes;
  • reduces the severity of pain;
  • eliminates swelling of the soft tissues located near the damaged joint.

As the intensity of inflammation decreases in the cartilage, blood circulation normalizes. They begin to receive molecular oxygen, nutrients and biologically active substances. Due to the improvement of calcium-phosphorus metabolism, bone destruction is slowed down. The chemical structure of chondroitin sulfate is similar to heparin. Therefore, it is able to prevent the formation of blood clots from fibrin in the synovial and subchondral microvasculature. This leads to a decrease in the intensity of pain in the joints and an increase in the range of motion in them. And the dimethyl sulfoxide contained in the external agent enhances the anti-inflammatory, analgesic and fibrinolytic activity of the chondroprotector.

Pharmacokinetics

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After dissolution of the gelatin capsule, about 75% of chondroitin sulfate is absorbed by the gastrointestinal mucosa. 13% of the total amount of chondroprotector penetrates the joint cavity after 4 hours. The maximum therapeutic concentration in the bloodstream is detected after 3,5 hours. Most of the active ingredient is concentrated in the synovial fluid and periarticular tissues. Its metabolism occurs in the cells of the liver. The chondroprotector is evacuated mainly by the urinary organs, and only a small amount is excreted during defecation in the composition of bile acids.

The active ingredient of the Chondroitin-Akos ointment does not penetrate the systemic circulation. After transepidermal absorption, it enters the foci of pathology after 2-3 hours.

Indications for use

Chondroitin-Akos is prescribed to patients who are diagnosed with diseases of the musculoskeletal system. It is used in the initial stages of pathologies – cervical, thoracic, lumbosacral osteochondrosis. When the first signs of osteoarthritis appear, the course of capsules helps prevent the destruction of cartilage, normalize the production of synovial fluid. Systemic and local preparations are used in rheumatological practice for the treatment of the following diseases:

The use of Chondroitin-Akos allows you to accelerate the healing of tissues after surgery. Ointment and capsules help accelerate the recovery of patients after dislocations, subluxations, fractures, sprains, or their complete separation from the bone base. Doctors recommend the use of chondroprotectors for people who are actively involved in sports and are subjected to heavy physical exertion.

So far, no drugs have been synthesized whose use prevents the development of osteoarthrosis. Therefore, therapy is carried out with drugs that control the course of the disease and slow down the growth of structural changes in the joints. Often they become drugs with chondroitin.

Contraindications

Chondroitin-Akos capsules are not used in the treatment of children under 15 years of age. Contraindication is individual sensitivity to the active or one of the auxiliary components. A systemic drug is prohibited for use by people prone to bleeding, and in the diagnosis of thrombophlebitis. The following contraindications are also characteristic of the ointment:

  • the presence of microtrauma in the area of ​​application – wounds, scratches, cracks, burns;
  • pathologies accompanied by necrotic tissue changes.

Pregnancy and lactation are not contraindications for chondroitin-Akos. But clinical studies of its teratogenic effects have not been conducted. Due to the lack of evidence of safety, medicines can be prescribed to patients only by a doctor.

Side effects

In the medical literature, cases of systemic side effects after local application of the ointment are not described. Sometimes sensitization reactions develop like hives:

  • erythema;
  • small rashes;
  • itching;
  • swelling and redness of the ep >

These side effects can occur when taking capsules, especially if there is a violation of the dosage regimen. Negative systemic reactions from the digestive organs were noted – nausea, vomiting, excessive gas formation, upset peristalsis. Less common are neurological disorders in the form of headaches, drowsiness, apathy.

Instructions for use

If the doctor has not prescribed a specific dosage regimen, then 2 capsules should be taken twice a day during or after meals. For optimal assimilation of chondroitin sulfate, it is necessary to drink the capsules with a glass of clean still water. The duration of the therapeutic course is 6 months. If necessary, the course of treatment can be repeated. The doctor takes into account that after discontinuation of the drug, its therapeutic effect lasts several months.

The ointment should be applied slightly above the area of ​​pain and inflammation 1-3 times a day with a thin layer. For better absorption, it must be rubbed into the skin. The course of treatment lasts from several weeks to 2 months, depending on the degree of tissue damage. After a month break, it can be repeated.

Chondroitin-Akos treatment leads to a decrease in the Leken index, a decrease in the intensity of pain during movement and at rest. Its course application allows you to adjust the dosage regimen. Rheumatologists reduce the number of non-steroidal anti-inflammatory drugs and glucocorticosteroids that have a toxic effect on the body.

Drug Interactions

During treatment with capsules, it should be borne in mind that chondroitin sulfate enhances the effect of:

  • anticoagulants – Heparin, Fraxiparin, Phenilin, Warfarin;
  • antiplatelet agents – acetylsalicylic acid, Curantyl, Parcedil, clopidogrel;
  • fibrinolytics – Streptokinases, Alteplases, Tenecteplases, Prourokinases.

Chondroitin-Akos can be used in combination with all systemic and local drugs used in the treatment of diseases of the musculoskeletal system.

Analogues

The chondroprotectors: Don, Chondroxide, Teraflex, Structum, Glucosamine-Maximum have the healing properties of Chondroitin-Akos capsules. A similar effect to the ointment is exerted by Chondroxide Forte, Arthro-Active from the blue line, Teraflex M, balm with chondroitin and glucosamine from the 911 series.

Dosage forms of the active analogues of ointment and capsules of Chondroitin-AkosName of drugs
Pills, capsules, drageesDon, Structum, Chondroxide, Arthro-Active, Honda, Teraflex, Glucosamine Maximum
Ointments, gels, balms, creamsTeraflex M, Chondroxide Forte, Chondroxide Maximum, Artro-Aktiv, Honda, Dikul balms
Solutions for parenteral administrationAlflutop, Dona, Chondrolon, Mucosat, Rumalon, Chondroitin

Chondroitin-Akos ointment and capsules is an effective drug for the treatment of articular pathologies. It is characterized by safety, affordability, ease of use at home. But these funds are used only as an additional therapy or for the prevention of diseases. To prescribe a full treatment, you need to contact a rheumatologist, vertebrologist or traumatologist.

Shishkevich Vladimir

Shishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews. It specializes in the treatment of diseases in orthopedic, traumatological, vertebrological profiles

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