Prednisone in the treatment of rheumatoid arthritis

Rheumatoid arthritis is a generalized autoimmune disease of a chronic nature that affects mainly joints, destroying its elements. The danger of this disease also lies in the fact that the process affects the connective tissue of many organs – the heart, liver, kidneys and others, which leads to their dysfunction. With rheumatoid arthritis, methotrexate is considered the drug of choice, the so-called “gold standard”, the use of which inhibits the activity of inflammatory changes and improves the general condition of the patient.

The drug is a folic acid antagonist, it stimulates the synthesis of adenosine, affecting the inflammatory and immune reactions by killing the cells involved in the provocation of inflammation in the joint tissues. In this case, methotrexate increases the synthesis of compounds with anti-inflammatory effect.

Injections into the knee joint with arthrosis: preparations and description

Prednisone is a synthetic analogue of the hormones cortisone and hydrocortisone, which are produced by the human body. The drug belongs to the medical group of corticosteroids.

Prednisolone is a very powerful drug with anti-allergic, anti-toxic, anti-shock and anti-inflammatory effects. But for such a wide range of applications you have to pay dearly: prolonged use of the drug is fraught with impaired renal and hepatic function and the development of side effects. Moreover, such problems are not excluded even when taking minimal doses of the drug.

Prednisolone tablets (100 pieces)

Prednisolone is often used in the treatment of arthritis (in particular rheumatoid). As a rule, they use it for severe arthritis with a risk of complications (for example, rheumatoid vasculitis).

Glucocorticosteroids have been used in the treatment of arthritis since the late 50s. During this time, doctors found that with the undoubted benefit of glucocorticosteroids, they also have a serious risk of side effects.

Glucocorticosteroids in general, and Prednisolone in particular, are one of the few drugs that positively affect the course of arthritis. Prednisone has several therapeutic effects that contribute to improving the patient’s condition.

List of possible therapeutic effects:

  1. A significant decrease in the severity of inflammatory processes, swelling.
  2. Improving mobility in the affected joints (usually temporary – until the end of therapy).
  3. Elimination or a significant decrease in the severity of autoimmune reactions that occur with arthritis.
  4. Slowing the progression of the disease, in rare cases – regression of the disease (but a complete cure, as a rule, is impossible).
  5. Significant reduction in joint pain.
  6. Improving the effectiveness of a basic anti-inflammatory therapy.
  7. Slowing down of articular destruction (however, destruction again begins to progress 3-6 months after the end of glucocorticosteroid administration).

Not in every case of the disease are glucocorticosteroids prescribed. There should be significant evidence: for example, the risk of severe autoimmune reactions in patients with rheumatoid arthritis.

Indications for the use of prednisone for arthritis:

  • the presence of severe pain, which in itself is a serious reason for limiting the patient’s working capacity;
  • severe inflammatory processes with a threat to generalization and prerequisites for the occurrence of autoimmune reactions;
  • the presence of autoimmune complications of arthritis with the threat of developing systemic autoimmune pathologies (including vasculitis of internal organs);
  • disease progression, or increased articular destruction in particular;
  • the development of partial or complete immobilization in a joint affected by arthritis, serious disability, prerequisites for disability of the patient;
  • the need to switch from non-steroidal anti-inflammatory drugs to other anti-inflammatory drugs (their use is too long).

The fastest and most convenient way to get rid of severe pain with arthrosis is an injection. The procedure itself, if it is carried out correctly, is painless, but if it comes to the knee joint, then unpleasant feelings just go through the roof.

  • Indications for injections in the knee joint with arthrosis
  • Types of injections
    • Corticosteroid injections in the joint
    • Hyaluronic Acid Injection
    • Chondroprotectors
  • Which injections are better to choose?
    • Contraindications
    • How is the procedure?
    • Price of treatment

Despite this, many people who suffer from excruciating attacks of pain in the knee joint are prepared to endure these injections. Below, we consider when injections into the knee are appropriate, how they are performed, and what drugs they are administered.

The importance of the knee joint is difficult to overestimate. Its mobility enables people to perform many movements that many people have on the machine. People begin to feel the joint only when an inflammatory process appears in the knee. Binding and severe pain, makes even ordinary movements simply impossible, which significantly interferes with living everyday life, and feelings of pain also torment morally.

As a rule, these diseases accompany elderly people who are characterized by wear and tear of the joint, against which the inflammatory process and swelling appear.

The effectiveness of injections into the knee joint is very high, since the drug passes to the very site of pain, instantly removing acute symptoms. Taking the same drugs orally, intravenously or intramuscularly, the speed of drug activation and its effectiveness is significantly reduced.

Also, injections have other advantages:

  • increase joint mobility;
  • strengthen periarticular muscles;
  • remove swelling and swelling of muscle fibers;
  • stimulate the joint;
  • improve blood microcirculation in the joint muscle of the joint.

Not all drugs can remove pain in the knee joint with arthrosis. There are three types of drugs that can relieve severe pain and relieve the condition of the knee joint:

  • Chondroprotectors – organize proper nutrition of the cartilage, activating and normalizing its performance;
  • Hyaluronic acid – best suited if there is a lack of synovial fluid in the joint that is responsible for knee mobility;
  • Corticosteroids – instantly relieve pain, but do not remove its cause.

We will analyze in more detail all categories of injections with a detailed description of medications.

Prednisolone is a very powerful drug with anti-allergic, anti-toxic, anti-shock and anti-inflammatory effects. But for such a wide range of applications you have to pay dearly: prolonged use of the drug is fraught with impaired renal and hepatic function and the development of side effects. Moreover, such problems are not excluded even when taking minimal doses of the drug.

Since Prednisolone is not the safest drug, it is not surprising that it has an impressive list of contraindications. It is forbidden to ignore contraindications – this is fraught with severe damage to internal organs and death.

  1. Severe hypertension.
  2. Diabetes mellitus and / or Itsenko-Cushing’s disease.
  3. Period of pregnancy.
  4. Presence of nephritis (inflammation of the kidneys) or endocarditis (inflammation of the inner walls of the heart).
  5. Peptic ulcer of the stomach and / or duodenum.
  6. Senile age of the patient.
  7. The active form of tuberculosis, syphilis.
  8. Circulatory failure of the third stage.
  9. Recently undergone surgery on any organ (including bone tissue).
  10. Psychoses, aggressiveness and violence of the patient, severe psychiatric diseases.

Sulfasalazine for rheumatoid arthritis: reviews on the use

Sulfasalazine is an antimicrobial, anti-inflammatory, immunosuppressive drug. According to its chemical structure, the drug is a combination of sulfapyridine (relieves inflammation due to good absorption) and 5-aminosalicylic acid (characterized by low intestinal absorption).

The preparation consists of 500 mg of sulfasalazine, excipients: starch, propylene glycol, magnesium stearate, silicon dioxide, povidone, hypromellose.

Prednisolone treatment regimen for rheumatoid arthritis

How to take prednisone with arthritis?

The dosage of prednisone for the treatment of arthritis is selected exclusively individually. With the occurrence of moderate arthritis, the initial dosage can be 20-30 mg per day (in tablets it is 4-6 pieces).

In severe cases of the disease, a dosage of 30-45 mg may be prescribed (intravenous administration, slowly). Maintenance therapy after the elimination of acute pathological processes is approximately 5-10 mg per day.

Norm and Rheumatoid Arthritis

How to take the drug? Injections are done only in a hospital environment by representatives of nursing staff. Tablets should be drunk so that in the morning the maximum dose of the drug is taken, average during the day, and minimal in the evening. More detailed instructions are available in the annotation to prednisone.

The course of treatment can last from a couple of days to several weeks. As a rule, if “shock dosages” are used, then the course is several weeks, not more. When prescribing maintenance therapy (in minimum dosages), the duration of treatment can be several months.

When calculating the duration of treatment, a large amount of patient data is used. Particular attention is paid to the functionality of the patient’s liver and kidneys, since in the presence of nephrosis, prolonged therapy cannot be carried out (complications will be much harder than the benefits of such treatment).

If arthritis occurs with severe inflammatory processes or has an autoimmune character (or is complicated by it) – Prednisone becomes an indispensable medicine.

This drug is usually prescribed in the form of tablets for oral administration, and injections are required only for severe arthritis.

Prednisolone is included in the standard of the main drugs used to treat arthritis of various etiologies (causes). The use of prednisolone is extremely effective in the treatment plan, but long-term use of the drug is prohibited – serious kidney and liver damage is possible.

The dosage of prednisone for the treatment of arthritis is selected exclusively individually. With the occurrence of moderate arthritis, the initial dosage can be mg per day (in tablets it is 4-6 pieces).

In severe cases of the disease, a dosage of VMG may be prescribed (intravenous, slow). Maintenance therapy after the elimination of acute pathological processes is approximately 5-10 mg per day.

Methotrexate for rheumatoid arthritis: how effective is it?

Rheumatoid arthritis is a generalized autoimmune disease of a chronic nature that affects mainly joints, destroying its elements. The danger of this disease also lies in the fact that the process affects the connective tissue of many organs – the heart, liver, kidneys and others, which leads to their dysfunction. With rheumatoid arthritis, methotrexate is considered the drug of choice, the so-called “gold standard”, the use of which inhibits the activity of inflammatory changes and improves the general condition of the patient.

The drug is a folic acid antagonist, it stimulates the synthesis of adenosine, affecting the inflammatory and immune reactions by killing the cells involved in the provocation of inflammation in the joint tissues. In this case, methotrexate increases the synthesis of compounds with anti-inflammatory effect.

Injections into the knee joint with arthrosis: preparations and description

Prednisone is a synthetic analogue of the hormones cortisone and hydrocortisone, which are produced by the human body. The drug belongs to the medical group of corticosteroids.

Prednisolone is a very powerful drug with anti-allergic, anti-toxic, anti-shock and anti-inflammatory effects. But for such a wide range of applications you have to pay dearly: prolonged use of the drug is fraught with impaired renal and hepatic function and the development of side effects. Moreover, such problems are not excluded even when taking minimal doses of the drug.

Prednisolone tablets (100 pieces)

Prednisolone is often used in the treatment of arthritis (in particular rheumatoid). As a rule, they use it for severe arthritis with a risk of complications (for example, rheumatoid vasculitis).

Glucocorticosteroids have been used in the treatment of arthritis since the late 50s. During this time, doctors found that with the undoubted benefit of glucocorticosteroids, they also have a serious risk of side effects.

Glucocorticosteroids in general, and Prednisolone in particular, are one of the few drugs that positively affect the course of arthritis. Prednisone has several therapeutic effects that contribute to improving the patient’s condition.

List of possible therapeutic effects:

  1. A significant decrease in the severity of inflammatory processes, swelling.
  2. Improving mobility in the affected joints (usually temporary – until the end of therapy).
  3. Elimination or a significant decrease in the severity of autoimmune reactions that occur with arthritis.
  4. Slowing the progression of the disease, in rare cases – regression of the disease (but a complete cure, as a rule, is impossible).
  5. Significant reduction in joint pain.
  6. Improving the effectiveness of a basic anti-inflammatory therapy.
  7. Slowing down of articular destruction (however, destruction again begins to progress 3-6 months after the end of glucocorticosteroid administration).

Not in every case of the disease are glucocorticosteroids prescribed. There should be significant evidence: for example, the risk of severe autoimmune reactions in patients with rheumatoid arthritis.

Indications for the use of prednisone for arthritis:

  • the presence of severe pain, which in itself is a serious reason for limiting the patient’s working capacity;
  • severe inflammatory processes with a threat to generalization and prerequisites for the occurrence of autoimmune reactions;
  • the presence of autoimmune complications of arthritis with the threat of developing systemic autoimmune pathologies (including vasculitis of internal organs);
  • disease progression, or increased articular destruction in particular;
  • the development of partial or complete immobilization in a joint affected by arthritis, serious disability, prerequisites for disability of the patient;
  • the need to switch from non-steroidal anti-inflammatory drugs to other anti-inflammatory drugs (their use is too long).

The fastest and most convenient way to get rid of severe pain with arthrosis is an injection. The procedure itself, if it is carried out correctly, is painless, but if it comes to the knee joint, then unpleasant feelings just go through the roof.

  • Indications for injections in the knee joint with arthrosis
  • Types of injections
    • Corticosteroid injections in the joint
    • Hyaluronic Acid Injection
    • Chondroprotectors
  • Which injections are better to choose?
    • Contraindications
    • How is the procedure?
    • Price of treatment

Despite this, many people who suffer from excruciating attacks of pain in the knee joint are prepared to endure these injections. Below, we consider when injections into the knee are appropriate, how they are performed, and what drugs they are administered.

The importance of the knee joint is difficult to overestimate. Its mobility enables people to perform many movements that many people have on the machine. People begin to feel the joint only when an inflammatory process appears in the knee. Binding and severe pain, makes even ordinary movements simply impossible, which significantly interferes with living everyday life, and feelings of pain also torment morally.

As a rule, these diseases accompany elderly people who are characterized by wear and tear of the joint, against which the inflammatory process and swelling appear.

The effectiveness of injections into the knee joint is very high, since the drug passes to the very site of pain, instantly removing acute symptoms. Taking the same drugs orally, intravenously or intramuscularly, the speed of drug activation and its effectiveness is significantly reduced.

Also, injections have other advantages:

  • increase joint mobility;
  • strengthen periarticular muscles;
  • remove swelling and swelling of muscle fibers;
  • stimulate the joint;
  • improve blood microcirculation in the joint muscle of the joint.

Not all drugs can remove pain in the knee joint with arthrosis. There are three types of drugs that can relieve severe pain and relieve the condition of the knee joint:

  • Chondroprotectors – organize proper nutrition of the cartilage, activating and normalizing its performance;
  • Hyaluronic acid – best suited if there is a lack of synovial fluid in the joint that is responsible for knee mobility;
  • Corticosteroids – instantly relieve pain, but do not remove its cause.

We will analyze in more detail all categories of injections with a detailed description of medications.

Prednisolone is a very powerful drug with anti-allergic, anti-toxic, anti-shock and anti-inflammatory effects. But for such a wide range of applications you have to pay dearly: prolonged use of the drug is fraught with impaired renal and hepatic function and the development of side effects. Moreover, such problems are not excluded even when taking minimal doses of the drug.

Since Prednisolone is not the safest drug, it is not surprising that it has an impressive list of contraindications. It is forbidden to ignore contraindications – this is fraught with severe damage to internal organs and death.

  1. Severe hypertension.
  2. Diabetes mellitus and / or Itsenko-Cushing’s disease.
  3. Period of pregnancy.
  4. Presence of nephritis (inflammation of the kidneys) or endocarditis (inflammation of the inner walls of the heart).
  5. Peptic ulcer of the stomach and / or duodenum.
  6. Senile age of the patient.
  7. The active form of tuberculosis, syphilis.
  8. Circulatory failure of the third stage.
  9. Recently undergone surgery on any organ (including bone tissue).
  10. Psychoses, aggressiveness and violence of the patient, severe psychiatric diseases.

Sulfasalazine for rheumatoid arthritis: reviews on the use

Sulfasalazine is an antimicrobial, anti-inflammatory, immunosuppressive drug. According to its chemical structure, the drug is a combination of sulfapyridine (relieves inflammation due to good absorption) and 5-aminosalicylic acid (characterized by low intestinal absorption).

The preparation consists of 500 mg of sulfasalazine, excipients: starch, propylene glycol, magnesium stearate, silicon dioxide, povidone, hypromellose.

New in the treatment of rheumatoid arthritis: modern approaches and drugs

Rheumatoid arthritis is a special disease that has been monitored by rheumatologists around the world for decades. Such close attention is due to its high social and medical importance. It is common among 0,5-2% of the population in developed industrial countries. In those suffering from this disease, life expectancy is reduced by 3-7 years. Huge damage is caused to society by the fact that premature disability of patients occurs, occurring in the first five years after the onset of the disease in the absence of timely treatment. What is new in the treatment of rheumatoid arthritis invented? About it further.

Rheumatoid arthritis is an inflammatory disease of a chronic nature with an unclear etiology that affects periarticular tissues and peripheral synovial joints, characterized by autoimmune defects, leading to destruction of articular cartilage and bone.

The origin of the disease is quite complicated and is still not well understood. However, the key factors are well known, and based on them are determined the methods of treatment of rheumatoid inflammation, in which serious progress has recently been achieved.

To consider what’s new in the treatment of rheumatoid arthritis openly, you need to know what the therapy is.

Rheumatoid arthritis treatment

In order to successfully treat rheumatoid arthritis, an integrated approach is needed. In particular, patients should be helped to solve social, psychological and domestic issues. Sometimes non-drug methods contribute to improvement.

In certain cases, limiting the load on the inflamed joints can be beneficial. To maintain their immobility, tires are used. Various orthopedic (and not only) devices, which allow it to fix and prevent the displacement of surfaces, help to improve joint functions and relieve pain.

An important role is also played by physiotherapy, which preserves muscle strength and range of motion of the joints without increasing inflammatory processes. The daily and professional life activity of patients should be restructured in such a way as to contribute to maximizing the quality of life and working capacity without overloading the joints. So what’s new in treating rheumatoid arthritis?

Modern approaches to therapy

The main goal of modern treatment is non-specific suppression of inflammatory reactions in the body and reduction of immune changes. However, such techniques can only improve the general condition and prolong remission, while reducing all destructive processes in the joints. A complete cure does not occur. Modern treatments for rheumatoid arthritis are worth considering.

Currently, when medical technologies are becoming more advanced, it has become known that a chronic inflammatory process develops in connection with the activation of immunocompetent cells – T-lymphocytes and macrophages. As a result, cellular mediators are released that provoke the growth of immune complexes (rheumatoid factors), in 80% of cases found in the blood during analysis. Their occurrence is promoted by an increase in connective tissue in the synovial articular membrane, causing inflammation. Modern treatments for rheumatoid arthritis include:

  • nonsteroidal anti-inflammatory drugs;
  • synthetic base anti-inflammatory drugs;
  • antibacterial therapy;
  • glucocorticoid drugs.

The basis of drug treatment are two directions:

  • suppression of too high activity of the immune system;
  • blocking the production of mediators that provoke inflammation.

Nonsteroidal anti-inflammatory drugs

Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) gives a good result, since pain activity decreases by several hours, but there is no lasting effect. The drugs greatly facilitate the patient’s life, but it is not possible to cure arthritis using NSAIDs, since the withdrawal of their intake again resumes the pain.

First, less toxic drugs are prescribed that are quickly absorbed by the body and easily excreted: “Movalis”, “Ibuprofen”, “Naklofen”, “Diclofenac”. Heavier drugs – Ketorolac and Indomethacin – are prescribed last, as, in addition to higher toxicity and prolonged excretion, they can have a side effect on the kidneys and liver.

When choosing NSAIDs, it should be borne in mind that the lack of effect in the first 3-5 days signals the need to replace the drug with another. The latest treatments for rheumatoid arthritis are of interest to many.

Treatment with basic anti-inflammatory drugs

The use of basic anti-inflammatory drugs is an important component of the treatment of arthritis in all patients who have no contraindications to such drugs. It is optimal to prescribe such therapy at the beginning, since the effect during this period will be most pronounced.

Drugs in this category contribute to the continuation of remission, quickly improve laboratory parameters, reduce the clinical manifestations of the disease and inhibit joint destruction. The presence of a large number of side effects determines that treatment with such agents should be carried out under strict control. The effect appears within a few weeks, and the result may be short-lived. Improvement will show laboratory tests: the level of white blood cells, protein in the blood and ESR is reduced.

Two groups of basic therapy drugs are distinguished:

  • The most effective are Methotrexate, Leflunomide, Cyclophosphamide.
  • Less effective and more toxic.

What are the most modern drugs for the treatment of rheumatoid arthritis?

Studies show that Cyclosporin is highly effective if taken in large doses, although it negatively affects the stomach and kidneys. Reducing the dosage makes the treatment process long, but the load on the body is negligible. The use of Cyclosporine with Methotrexate is more successful than their separate administration. Arthritis can be cured using basic therapy for two to three years or more.

Hormonal treatment

Hormone therapy plays an important role in the treatment of arthritis, as it can affect many metabolic processes in the body. In order to relieve inflammation, hormones of the adrenal cortex are commonly used.

Such drugs include Prednisone and Prednisone. They are administered intravenously or in the joint itself. Hormone therapy is used in severe forms of rheumatoid arthritis.

Choose a drug, route of administration and dosage, taking into account individual characteristics. It is worth remembering that even the newest hormonal drugs are steroids that subject the human body to significant changes, which in most cases are irreversible. Modern methods in the treatment of rheumatoid arthritis involve the use of biological agents.

Biological agents

The use of biological drugs, in contrast to the basic ones, gives a faster effect that occurs within a few weeks. Means that fall into this category are used together with non-steroidal anti-inflammatory and hormone therapy.

The binding of necrosis growth factor contributes to Etanercept. The drug “Anakinra” is less effective and is prescribed in rare cases, if the blockers do not give a positive result. “Abatacept” is used for severe rheumatoid arthritis: it blocks the functioning of the immune system and prevents T cells from becoming active in the body. New methods of treating rheumatoid arthritis in Russia are used more and more often.

To date, the following biological agents are used: “Kinneret”, “Orentia”, “Enbrel”, “Rituxan”, “Humira”, “Remicade”. The only drawback of these medications is their high cost. To get a new arthritis therapy in Russia, you can use the state quota system.

Biological preparations should be taken carefully, medications should be administered only under the supervision of specialists in a hospital. Drug administration can last several hours. Such drugs are prescribed for patients with a suppressed immune system after a preliminary comprehensive examination for tuberculosis, oncology and sexually transmitted diseases. Such measures are necessary because the drugs of this group seriously affect the immune system and weaken it.

Timely and competent treatment of rheumatoid arthritis helps to achieve high results in the shortest possible time. During an exacerbation of the disease, you need to increase the dosage and undergo hospitalization in an inpatient setting. Interrupt inflammatory processes and pain with the help of hormonal drugs.

We examined what is currently new in the treatment of rheumatoid arthritis. We hope this information is helpful.

How to take prednisone with arthritis?

If arthritis occurs with severe inflammatory processes or has an autoimmune character (or is complicated by it) – Prednisone becomes an indispensable medicine. This drug is usually prescribed in the form of tablets for oral administration, and injections are required only for severe arthritis.

Prednisolone is included in the standard of the main drugs used to treat arthritis of various etiologies (causes). The use of prednisolone is extremely effective in the treatment plan, but long-term use of the drug is prohibited – serious kidney and liver damage is possible.

1 Brief description of the drug

Prednisone is a synthetic analogue of the hormones cortisone and hydrocortisone, which are produced by the human body. The drug belongs to the medical group of corticosteroids.

Prednisolone is a very powerful drug with anti-allergic, anti-toxic, anti-shock and anti-inflammatory effects. But for such a wide range of applications you have to pay dearly: prolonged use of the drug is fraught with impaired renal and hepatic function and the development of side effects. Moreover, such problems are not excluded even when taking minimal doses of the drug.

Prednisolone is often used in the treatment of arthritis (in particular rheumatoid). As a rule, they use it for severe arthritis with a risk of complications (for example, rheumatoid vasculitis).

Glucocorticosteroids have been used in the treatment of arthritis since the late 50s. During this time, doctors found that with the undoubted benefit of glucocorticosteroids, they also have a serious risk of side effects.

Shishkevich Vladimir, orthopedic and traumatologistShishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews.

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1.1 What is the effect of prednisone on arthritis?

Glucocorticosteroids in general, and Prednisolone in particular, are one of the few drugs that positively affect the course of arthritis. Prednisone has several therapeutic effects that contribute to improving the patient’s condition.

List of possible therapeutic effects:

  1. A significant decrease in the severity of inflammatory processes, swelling.
  2. Improving mobility in the affected joints (usually temporary – until the end of therapy).
  3. Elimination or a significant decrease in the severity of autoimmune reactions that occur with arthritis.
  4. Slowing the progression of the disease, in rare cases – regression of the disease (but a complete cure, as a rule, is impossible).
  5. Significant reduction in joint pain.
  6. Improving the effectiveness of a basic anti-inflammatory therapy.
  7. Slowing down of articular destruction (however, destruction again begins to progress 3-6 months after the end of glucocorticosteroid administration).

1.2 When do you take prednisone for arthritis?

Not in every case of the disease are glucocorticosteroids prescribed. There should be significant evidence: for example, the risk of severe autoimmune reactions in patients with rheumatoid arthritis.

Indications for the use of prednisone for arthritis:

  • the presence of severe pain, which in itself is a serious reason for limiting the patient’s working capacity;
  • severe inflammatory processes with a threat to generalization and prerequisites for the occurrence of autoimmune reactions;
  • the presence of autoimmune complications of arthritis with the threat of developing systemic autoimmune pathologies (including vasculitis of internal organs);
  • disease progression, or increased articular destruction in particular;
  • the development of partial or complete immobilization in a joint affected by arthritis, serious disability, prerequisites for disability of the patient;
  • the need to switch from non-steroidal anti-inflammatory drugs to other anti-inflammatory drugs (their use is too long).

1.3 Prednisolone for rheumatoid arthritis (video)

1.4 When can not be taken?

Since Prednisolone is not the safest drug, it is not surprising that it has an impressive list of contraindications. It is forbidden to ignore contraindications – this is fraught with severe damage to internal organs and death.

  1. Severe hypertension.
  2. Diabetes mellitus and / or Itsenko-Cushing’s disease.
  3. Period of pregnancy.
  4. Presence of nephritis (inflammation of the kidneys) or endocarditis (inflammation of the inner walls of the heart).
  5. Peptic ulcer of the stomach and / or duodenum.
  6. Senile age of the patient.
  7. The active form of tuberculosis, syphilis.
  8. Circulatory failure of the third stage.
  9. Recently undergone surgery on any organ (including bone tissue).
  10. Psychoses, aggressiveness and violence of the patient, severe psychiatric diseases.

2 How to take prednisolone for arthritis: duration, dosage, rules of administration

The dosage of prednisone for the treatment of arthritis is selected exclusively individually. With the occurrence of moderate arthritis, the initial dosage can be 20-30 mg per day (in tablets it is 4-6 pieces).

In severe cases of the disease, a dosage of 30-45 mg may be prescribed (intravenous administration, slowly). Maintenance therapy after the elimination of acute pathological processes is approximately 5-10 mg per day.

Norm and Rheumatoid Arthritis

How to take the drug? Injections are done only in a hospital environment by representatives of nursing staff. Tablets should be drunk so that in the morning the maximum dose of the drug is taken, average during the day, and minimal in the evening. More detailed instructions are available in the annotation to prednisone.

The course of treatment can last from a couple of days to several weeks. As a rule, if “shock dosages” are used, then the course is several weeks, not more. When prescribing maintenance therapy (in minimum dosages), the duration of treatment can be several months.

When calculating the duration of treatment, a large amount of patient data is used. Particular attention is paid to the functionality of the patient’s liver and kidneys, since in the presence of nephrosis, prolonged therapy cannot be carried out (complications will be much harder than the benefits of such treatment).

Morozov Georgiy

Georgy Morozov, rheumatologist. For more than 20 years, he has been involved in the diagnosis, treatment and prevention of joint diseases.

Expertnews