- Has achieved remission of rheumatoid arthritis. So inspired that she became an instructor)))
- Rheumato >
- Modern treatment of rheumato >
- Basic pharmacotherapy in rheumatology
- Modern treatment in rheumatology
- Types of Biological Preparations
- The main advantages of biologically active drugs
- The disadvantages of biological therapy
- Genetic Engineering Will Help Overcome Rheumatoid Arthritis
Has achieved remission of rheumatoid arthritis. So inspired that she became an instructor)))
Since childhood, I hated all physical activity. I don’t know why, but physical education lessons were a complete test for me, and aerobics (it was introduced instead of physiologists) at the University caused pathological horror. Perhaps because I didn’t have enough energy since childhood, and I didn’t want to waste it on doing silly gestures (as it seemed to me then). That is, you are already almost always tired, and then strain, sweat! No, this is not for me . I thought. Where is it better to read a book, sitting on a sofa or just walk quietly.
Until my life turned upside down and at 25, I was not given a formidable diagnosis of rheumatoid arthritis. At that time there were no special alternatives, and terrible anguish appeared on my soul, because the prospects of getting into a wheelchair were depressing. 11 years ago, they only heard about joint replacement, and about genetically engineered drugs you could only read on the Internet.
Terrible days have begun. Do you know how to live constantly with terrible pain? When it is impossible to touch you, you scream in pain, put on tights for 20 minutes and cannot pick up a mug of tea. Drug therapy did not help me, and in the struggle for my health I couldn’t do anything – from eating a raw beating heart of a chicken (this is the healer alone tried to treat me) to being buried in a trench with burning coals and herbs. Only the treatment in the sanatorium helped me (the link will be at the bottom of the review), but only for 2 months (((For the boss ran into me at work for no reason, and I started to worry about it unreasonably. Yes, I got so excited that I got another exacerbation on Oh, if I had the current brains, I would have defeated him with psychological Aikido, but . you can’t return the former.
Since then, I could not get away from the pain, and decided to make a knight’s move! Namely, to become pregnant and have a baby, for subsequent prospects were foggy. Praise heaven, it was all done for me, but after giving birth there was such an exacerbation of the disease that I stayed on this earth for 1,5 years only because I had a son and mother. I really wanted to leave, I will not hide. I repeat once again that the drugs only hurt me.
And at one of the forums I came across the topic of breathing-meditation practices and learned about the dynamic form of qigong – tai chi (Taijiquan). There, a man (and now my friend from Estonia) wrote that he was able to defeat the disease thanks to daily 2-hour classes. And I grabbed this straw! By a fortunate coincidence, I found in Ufa a Doctor of the highest category who treated patients only to him!
I came to him in a deplorable state. I had hormone dependence (2 years on prednisone), I sat tight on the NSAIDs, although they did not help me. I could not comb myself, I had terribly swollen legs (secondary lymphostasis) and terrible despair in my eyes. From the first lesson, I began to improve.
I could not believe it! He showed me only 3 exercises that I did with grief in half, and such an effect. How so?
Gap pattern in my head. But my joints, already used to years of lack of movement, then became aggravated. It was also strange – such simple movements, classes last 15-20 minutes with long intervals between exercises, and so affect the body. So yes. I had to make forms, clenching my teeth and with tears, the size of a fist.
Thank God, after 10 days it all went away and improvement began again. And so in the ascendant – it got better, then worse, again good and again everything is bad. Gradually, for 5 months I was able to quit all pills (I quit hormones before class, although it was very hard for me).
After about 8 months, I began to feel indestructibly healthy. And indeed, I participated in skiing, ran, and everything was nothing to me!
Only 16 exercises that can be performed by any person from 5 years to 95. True, every day 2 times.
More than 6 years have passed since then, and this is a mandatory ritual. This is what helped me decide to have a second baby and again to overcome the exacerbation. I am now 11 years old with a diagnosis until I have a disability. Remember, I don’t have a cure! Yes, alas, deformities after the second birth appeared, but they are not critical.
I have excellent memory, my head is also good, excellent performance. All this is rare with autoimmune. I also look much younger than my 35 years. Of course, the age and length of illness take their toll, but usually they are associated with the fact that I start or skip classes, or do them for free (oh, human nature!). Now I am writing a review and again inspired to practice.
I even became an instructor and now train everyone (especially patients with rheumatoid arthritis). This is not a panacea, but it qualitatively improves a person’s life. And one girl even became pregnant a month after class!
We got good results with a girl with multiple sclerosis.
There is nothing to talk about osteochondrosis and back problems – these problems disappear during the first month of classes.
My Master taught people who, thanks to Chinese gymnastics, were healed of many types of oncological diseases, etc.
I recommend that practice to everyone! It is advisable, of course, to do it under the guidance of a competent instructor. Warning your questions, I’ll say that if you don’t have the opportunity to attend group classes, it’s worth watching the videos of foreign Masters on the Internet.
Hello. My question is caused by my daughter’s illness: Svetlana is 30 years old, she is diagnosed with rheumatoid arthritis. The disease began six years ago: literally on the eve of the wedding, she began to feel pain in the ankle joint; the pain gradually intensified and the area of its localization expanded, after three months all the joints ached, it was even hard for her to walk, and the therapist in the clinic could not say what kind of illness it was. Even in the hospital, the diagnosis was not immediately made, but when they did, they were discharged home and prescribed methotrexate. We stretched out for almost another six months, because such a treatment is similar to chemistry with all the consequences. Sveta tried various home remedies – warming, massage, rubbing – to relieve pain, drank painkillers, but then she started taking the drug.
After about a year, the condition seemed to be stable and methotrexate was abandoned, but the improvement did not last even three months. Again methotrexate for a year and a half, after which the improvement lasted almost nine months and the daughter and her husband really hoped that you could think about children – both very much want children. But the disease returned and very acutely, the doctors again insisted on methotrixate. My daughter spoke with other patients, for some reason they did not prescribe anything other than methotrexate.
Now she has been using the drug for two years at 10 mg per week, side effects are noticeably manifested: she gets very tired, gets tired quickly, her hair has thinned, she is psychologically constantly on the verge of depression – she really wants children, and the years pass.
My soul was ill about Svetochka, well, is there really nothing else but this hard medicine? Maybe in Israel there are already some drugs to cure patients diagnosed with rheumatoid arthritis, or at least taking them does not prevent pregnancy?
Hello Olga! First, of course, there are other drugs besides Methotrexate that are used to treat rheumatoid arthritis. In Israel, during pregnancy, patients with rheumatoid arthritis are most often prescribed steroid drugs. In addition, there are still new, biological drugs that are used together with methotrexate for patients who do not respond to treatment with methotrexate alone, but this is only after pregnancy. But I would also advise double-checking the diagnosis, since you yourself said that you could not understand what was happening to your daughter for a long time, and (perhaps) the diagnosis was not made correctly.
Pregnancy with the development of rheumatoid arthritis is difficult. During such a pregnancy, a woman should be observed by a rheumatologist. The specialist is likely to cancel or reduce the dosage of medication. Usually, during pregnancy, the hormones improve under the influence of hormones, but after giving birth a sharp deterioration is possible. A woman who has decided to become pregnant, despite future difficulties, must consider the main factors that arise with rheumatoid arthritis.
– no need to wait for remission;
– it is necessary to undergo a thorough examination not only of the joints, but also of the heart and discuss pregnancy planning with the doctor,
– before conception, it is necessary to cancel medicines that can adversely affect the course of pregnancy and the fetus, these include methotrexate;
– during pregnancy, specialists prescribe a woman small doses of corticosteroids, which do not pose a threat to the fetus. As for the main, more aggressive treatment for the fetus, it stops completely.
Of course, it is necessary to double-check the diagnosis. Rheumatology is a huge branch of medicine. There are thousands of diseases that are somewhat similar to rheumatoid arthritis. Yes, there are effective medications for treatment.
Maria, I read all the answers several times, I sit and cry. And from the joy that there are chances, and from the chagrin that everything is completely different with us. You write about treatment during pregnancy, and doctors do not allow Svetochka to become pregnant at all. They say that this issue can only be discussed if the remission is prolonged, no less than 6–9 months without taking any medications, and only if you feel really good all this time. And in truth – they generally dissuade that even if everything works out and suddenly an aggravation happens, you still have to interrupt the pregnancy. Where we have to double-check that, in our northern regions there were several times a couple of specialists and it turned out to be wrong, all the years that Svetochka was ill she was observed by the same doctors. This time, when the side effects started to bother me very much, I went to the doctor without my daughter, asked if I could have another treatment whatsoever, maybe I could go to a consultation. And he said, if there is a lot of extra money, at least to Moscow, at least fly to St. Petersburg, they will tell you the same thing there and appoint the same methotrixate. Thank you Maria, now at least we know that there are chances.
Galina, I have already described the situation above Maria. As you paint the algorithm, we can only dream of such a thing. A woman lay with Svetochka in the hospital, told, she decided to give birth, and when she became pregnant, she went to get registered, the first thing they did was to receive a receipt that there were no complaints against the doctors. And when the exacerbation began, she was not picked up for treatment, but forced to have an abortion. Why did I start to find out everywhere – Svetochka decided to get a divorce with her. The other day, she came to us like she was bored, and then she says: I’ll file for divorce, I’m tired of this disease and I don’t want to ruin my life, I don’t know if I can give birth to it, but he wants children, he can find himself healthy and will be with her happy. Even before the wedding, they dreamed of children, he and his neighbors were always busy, building slides for them, filling the rink in winter, mastering something in the summer. My father and I barely talked her out; she didn’t want to return home at all. I will show her that you, Maria and Victor answered – I will please her that there is still hope that it is too early to put an end to yourself.
Victor, and thank you for the answer. Above, I’ve already painted everything and I’m grateful to all three of you, you gave me hope, I now find myself in such a good sense of the feeling – not to convey. Here I will show Svetochka and our men (husband and son-in-law) your answers, and then we will think together.
Olga, hello. That is, when you were already diagnosed, did you not take the drug prescribed for your daughter for another half a year? Sorry, but what did you hope that would resolve itself after lotions and rubbing? And then, when it became easier, you again took and canceled your drug yourself? That is, you understand that the disease is serious and decided that it can be cured by lotions or prescribe and cancel the medicine for yourself? I marvel at you, honestly. Do not trust these doctors, go to others, but do not prescribe and cancel serious drugs for yourself. What does it mean there are no doctors, you do not live on a distant island, where the plane flies once every six months and in good weather that you could not consult other doctors.
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Mom, 62 years old, has had rheumatoid polyarthritis for a long time, but already as a year in serious condition and no treatment helps. X.
Modern treatment of rheumato >
Modern treatment in rheumatology is based on carefully selected medical therapy, using all the latest achievements of medical science. This is the main and most effective form of care for rheumatological diseases.
Basic pharmacotherapy in rheumatology
Medicines act on the main pathogenetic factor of the disease – they suppress autoimmune activity and have a direct anti-inflammatory effect. Usually, pharmacotherapy in rheumatology involves taking the following groups of drugs:
- Basic anti-inflammatory drugs are the most important element of drug treatment, slowly (within one to three months), but surely suppressing the activity of the disease, used for a long time (sometimes for years).
- Glucocorticoids are hormonal drugs that have powerful fast anti-inflammatory effects. They are used more often for a short time, before the onset of the effect of the basic drugs.
- Nonsteroidal anti-inflammatory drugs – used in short courses, mainly with the goal of reducing or relieving pain.
Modern treatment in rheumatology
Detailed studies of the mechanisms of development of the autoimmune inflammatory process in the last 10 years have allowed the creation of a new class of drugs – genetic engineering biological drugs that have a selective point effect on key parts of the inflammatory process.
Medical biological preparations used in rheumatology are human or animal antibodies to inflammatory mediators – molecules that transmit inflammatory signals (tumor necrosis factor-α – TNF-α, interleukins, cytokines, etc.), or to proteins of excessively active T and B- lymphocytes (cells of the immune system).
Inflammatory mediators are substances that are excessively formed in the body during an autoimmune disease and support the inflammatory process, including in the articular membrane (synovitis), blood vessels (vasculitis), and skin. Biological products block them, stopping inflammation and erosion of cartilage, destruction of adjacent bone tissue. Allow much faster (within a few days) to achieve all the positive effects of basic anti-inflammatory therapy (suppression of autoimmune aggression, subsidence of inflammation, interruption of exacerbation, preservation of the articular surface). Each drug blocks one specific link in the inflammatory cascade. The accuracy of the exposure determines the best tolerance of treatment and fewer side effects.
Biological products are administered intravenously or as a subcutaneous injection 1-2 times a month for a long period (up to a year or more).
The production of these drugs requires complex biotechnology and genetic engineering, which leads to high cost. However, the effectiveness of biological products is worth the money.
Types of Biological Preparations
Inhibitors (blockers) of TNFα
- Infliximab (Remicade)
- Golimumab (Simponi)
- Adalimumab (Humira)
- Tsertolizumab pegol (Simzia)
- Etanercept (Enbrel)
Reducing the activity of interleukins
- Anakinra (Galilee)
- Tocilizumab (Actemra)
- Ustekinumab (Stelara)
- Kanakinumab (Ilaris)
- Rituximab (MabThera)
- Belimumab (Benlista)
Anti-T Cell Therapy
The main advantages of biologically active drugs
- Fast action – they stop inflammation and inhibit joint destruction after several days of use (compared with 1-3 months before the obvious clinical effect with conventional basic therapy).
- The possibility of combining with traditional drugs, accelerating and enhancing their action.
- Efficiency in a number of cases resistant to traditional therapy (up to 84%). Early treatment provides a better outcome. Combination therapy of biologics with methotrexate (a basic therapy drug) is more effective than treatment with a single drug.
- Efficiency is confirmed by clinical, laboratory and instrumental methods:
- a decrease in the level of inflammatory indicators (ESR, CRP), the Russian Federation (rheumatoid factor);
- improvement of the state of cartilage tissue according to x-ray studies – the absence of new erosion, a tendency to healing old;
- increase of motor activity and quality of life of patients, preservation of their working capacity.
The disadvantages of biological therapy
- Suppression of immunity, increased risk of infectious complications.
- The possibility of developing allergic reactions to the drugs themselves (foreign protein).
- Expensive treatment.
Contraindications to biotherapy:
- The patient has active tuberculosis, hepatitis B and C, herpetic and HIV infection.
- Pneumonia, bronchitis, sinusitis, erysipelas, urinary tract infection, diverticulitis, local infections, septic arthritis, sepsis, etc.
- Malignant neoplasms.
Important! These contraindications (especially infectious) are relevant exclusively in the active period of the disease. After conducting effective antibacterial or antiviral therapy, the use of biological drugs is possible.
In the treatment of rheumatoid arthritis, new genetically engineered drugs give hope to many patients with a stubborn, resistant course of the disease to conventional therapy.
In the network of clinics “Capital” you will undergo treatment of rheumatological diseases using the most modern pharmacotherapy, innovative technologies of extracorporeal hemocorrection, which significantly improve the results of therapy, physiotherapy, orthopedic care.
Genetic Engineering Will Help Overcome Rheumatoid Arthritis
On October 12, World Health Organization (WHO) initiated World Arthritis Day. On the eve of it, leading Russian experts, including the founder of Russian rheumatology, academician of the RAMS Valentina Aleksandrovna Nasonova, told the media about the dangers of the most insidious of all rheumatic diseases – rheumatoid arthritis. According to unofficial data, this disease in Russia affects more than 1 million people – almost every th resident of the country.
The increase in the prevalence of rheumatic diseases today occurs in all countries of the world. Rheumatoid arthritis alone affects more than 20 million people on the planet. This is the most dangerous disease, inevitably leading to disability. Most often, rheumatoid arthritis affects working people aged 30 to 50 years. Women suffer from this disease 5 times more often than men. Five years after the onset of the disease, half of the patients become disabled and lose their working capacity.
The official Russian morbidity statistics differ significantly from the unofficial data: there are a little more than 300 thousand patients with rheumatoid arthritis. This discrepancy is due to the fact that doctors (as a rule, general practitioners who come to such a patient for an initial appointment) are often unable to make a correct diagnosis due to the large number of “masks” that rheumatoid arthritis may take at the beginning of its development. The insidiousness of the disease lies in the fact that not only the joints, but also the internal organs are very often affected. And as a consequence of this, the problem of “hidden mortality” arises when many patients die, for example, of heart failure, which is actually caused by rheumatoid heart damage. For many years, this disease was considered difficult to treat – up to 30 percent of patients did not receive a positive result from traditional therapy.
Valentina Nasonova, academician of the Russian Academy of Medical Sciences, professor, Honorary President of the Association of Rheumatologists of Russia: “Russian rheumatology is a fairly young science. But over the past 40 years that I deal with it, there have been significant positive changes.
Over the years, a rheumatology service has been established in the country, continuing education courses for doctors are regularly held, rheumatology is successfully developing in Russia both as a science and as a practical discipline. Significant is the fact that the scientific achievements that appear in world medicine, we can now quickly implement in Russian practice. I can say with confidence that now we can fight even the most complex rheumatic diseases, and fight very effectively. ”
A few years ago, fundamentally new methods appeared: doctors began to use the so-called “biological agents” – innovative drugs that specifically affect the development of the inflammatory process in the joints. And last year, thanks to the efforts of the Roche company, monoclonal antibodies came to rheumatology, which proved to be effective in other equally serious areas of medicine, in particular, oncohematology. But, unfortunately, the availability of such medicines due to reduced funding for the DLO program has decreased significantly. More than 20% of patients (usually with severe, rapidly progressive forms of the disease) require the use of the most modern drug therapy. Meanwhile, only 1% of the number of officially registered patients receives such therapy.
Evgeny Nasonov, academician of the Russian Academy of Medical Sciences, professor, director of the Institute of Rheumatology of the Russian Academy of Medical Sciences, President of the Association of Rheumatologists of Russia: “Domestic rheumatologists today actively use the so-called biological products, which have become the best weapon in the treatment of rheumatoid arthritis. This was a breakthrough in world medicine, no less significant than the discovery of antibiotics. Antibodies such as rituximab, can significantly stop the development of the disease, maintain a high quality of life for patients even in those patients who previously did not help. Now the most important thing is for the state to pay attention to the problem of the disease and provide our patients with such modern drugs. Indeed, a high level of disability in rheumatoid arthritis results in a serious economic burden on society. The costs of the healthcare system for these patients are 3 times higher than average. ”
Shishkevich Vladimir, orthopedic and traumatologist, project editor-in-chief ExpertNews.
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